Pharmaceuticals, Life Sciences, and Biotechnology
Hygienic Mixing, Metering, and Dilution with LEWA Solutions
Producing pharmaceuticals requires special expertise to comply with stringent legal and regulatory standards. At LEWA, reliability in production, documentation, and validation are paramount. You can trust in our proven pumps, pump packages, and complete systems, extensively used across the pharmaceutical, life sciences, and biotechnology industries. Our experts are dedicated to helping you find optimal, customized solutions for your metering, purification, mixing, and filtration processes.
LEWA hygienic metering pumps, including the LEWA ecodos and LEWA ecoflow, meet all aseptic requirements necessary for manufacturing products with low bioburden or even in sterile conditions, making them the top choice in these critical applications.
Picture: Buffer inline dilution by means of LEWA hygienic metering pumps or as complete process skid are only one of many solution examples in the pharma and biotech industry.
Inline Dilution, Mixing, Dosing and Other Processes in the Pharmaceutical, Life Sciences, and Biotech Industries
Our LEWA systems feature specialized in-house engineering and meet all critical industry standards, including inline dilution and dosing requirements (cGMP, GAMP, 21 CFR, etc.). We provide comprehensive services such as complete documentation, acceptance tests, validation/qualification, installation, and commissioning.
LEWA system solutions are integral in various applications across the pharmaceutical, life sciences, and biotechnology markets. These include the precise metering of liquids, production of dispersions, high-pressure homogenization processes, and various mixing tasks. Our systems also excel in the dilution of buffers, handling of products or concentrates, and support diverse downstream processing (DSP) unit operations, demanding precise volume flows and strict adherence to specific process conditions.
| Product applications | Task | Process/System |
|---|---|---|
| Areas of application for our products and solutions in the pharmaceutical and biotechnology industries | Proportionally mixing sensitive, expensive fluids on a continuous basis | Metering additives for tablet production; tablet coatings, preservatives |
| Precisely adding fluids during the chromatography process | Dosing fluids into the purification process, diluting buffers and concentrates | |
| Metering sensitive fluids | Adding enzymes, vitamins, flavorings, and additives for fermentation | |
| Aseptically transferring proteins and cells | Adding micro-organisms to fermentations, transferring blood or blood components, transferring products in filling processes | |
| Adding additives | Additives, toxic chemicals | |
| Injecting fluids for extrusion or spraying mechanisms | Producing active ingredients and tablets, adding stabilizers | |
| Microfiltration and ultrafiltration, dialysis systems | Filtering process solutions, carefully concentrating intermediate products (biopharmaceuticals), concentrating and purifying protein solutions, separating cells and particles | |
| High-pressure and supercritical applications | Dispersing 2 phases, supercritical processes with CO2, generating nanoparticles |
Solutions for the Pharmaceutical, Life Sciences, and Biotech Industries
The biopharmaceutical, fine chemical, veterinary medicine, and special food supplement industries all require systems that are easy to clean and drain, and that are manufactured and documented according to the applicable guidelines. LEWA has the expertise to design and construct customer-specific systems for these industries.
Our scope of supply for these sectors ranges from simple metering systems for metering additives, dosing modules in process chromatography units and buffer dilution systems, right through to complex systems for the proportional mixing or conveyance of various media.
Process-Integrated Pump Systems for Filtration and Other Processes
We also use the LEWA intellidrive technology to solve difficult metering and conveying tasks:
- Applications that allow a minimum of pulsation such as sensitive chromatography media or fluids during filtration processes
- Highly viscous fluids such as syrup or gel
- Highly precise metering during filling jobs
- Hermetically sealed for hygienic and sterile processes
- Mixing of two fluids in one pump head such as gradient formulation in chromatography processes
- At varying flow rates and at inhomogeneous qualities, changing pressures, or temperatures
Metering Pumps in Hygienic Design
LEWA hygienic metering pumps (LEWA ecodos and LEWA ecoflow) are hermetically sealed, leak-free, and have no connection, such as a shaft, to the product space. This ensures contamination-free metering and conveying over a long process time frame.
Hygienic pumps can also be used as multiplex pumps (e.g., for metering formulas). This means that several pump drive units can be assembled on one drive shaft. The individual pumps then convey varying quantities into the process. To increase the safety of your aseptic and sterile production processes, LEWA hygienic pumps are tested for their cleanability according to recognized, internationally valid guidelines (EHEDG cleanability test and QHD test system).
Advantages of the LEWA Pumps and Metering Packages for the Pharmaceutical, Life Sciences, and Biotechnology Industries
High end pumps, equipment and systems
We deliver high-end pumps integrated into complete systems and units for your specific applications. In doing so, we of course rely on the tried-and-tested LEWA quality.
Economic solutions
We always deliver economic pumps, systems and units with minimized energy consumption, high efficiency, low maintenance and a long lifetime.
Tried and tested modular system
We design our systems and units in modular design with numerous engine and pump head combinations for different applications.
Special materials
On request, we can build systems with special materials such as Hastelloy, titanium, duplex stainless steel or further materials. If you are interested, please contact our product manager.
Patented sandwich diaphragm
Our patented diaphragm metering pumps use metal or PTFE sandwich diaphragms with Diaphragm Protection System (DPS) for maximum operational safety.
Sanitary & hygienic design
Highly polished surfaces and a minimal dead space construction are the basis for a system design that meets all the industry's hygienic standards.
Easy to clean
An especially important advantage for pharmaceutical and food industry is that our systems can be quickly and easily cleaned with cleaning chemicals or hot steam.
International standards
LEWA pumps, systems and units are compliant with major international standards such as DVGW G280, WHG, PED, ISO 9001, ASME, ATEX and TA-Luft. Of course, you can also define your own standards.
Maintenance and service
No matter if maintenance, spare parts or repair - our service technicians are well trained and available worldwide. Thus, we guarantee fast response and smooth operations.
