Pharmaceuticals, Life Sciences, and Biotechnology
Hygienic Mixing, Metering, and Dilution with LEWA Solutions
Special expertise is required in the production of pharmaceuticals in order to ensure that the legal and regulatory requirements are met.
Reliability when it comes to production, documentation, and validation are our top priorities. That's why you can rely on LEWA's tried-and-tested pumps, pump packages and complete systems for many processes in the pharmaceutical, life sciences, and biotechnology industries. Our experts will be happy to advise you on finding optimum, customized solutions for your metering, purification, mixing, and filtration processes.
LEWA hygienic metering pumps (LEWA ecodos and LEWA ecoflow) meet all aseptic requirements in these processes and are always the first choice when it comes to manufacturing low bioburden or even sterile products.
Picture: Buffer inline dilution by means of LEWA hygienic metering pumps or as complete process skid are only one of many solution examples in the pharma and biotech industry.
Inline Dilution, Mixing, Dosing and Other Processes in the Pharmaceutical, Life Sciences, and Biotech Industries
Our systems have in-house engineering and meet all the industry-relevant requirements, such as for inline dilution and dosing (cGMP, GAMP, 21 CFR, etc.). We also offer complete documentation, acceptance tests, validation/qualification, installation, and commissioning services.
System solutions from LEWA can be found in many applications in this market: from the metering of liquids, production of dispersions, homogenization processes at high pressures, various mixing tasks, processes for the dilution of buffers or handling product or concentrates right through to the diverse DSP unit operations. These tasks require precise volume flows and exact conformance with specific process conditions.
Product applications | Task | Process/System |
---|---|---|
Areas of application for our products and solutions in the pharmaceutical and biotechnology industries | Proportionally mixing sensitive, expensive fluids on a continuous basis | Metering additives for tablet production; tablet coatings, preservatives |
Precisely adding fluids during the chromatography process | Dosing fluids into the purification process, diluting buffers and concentrates | |
Metering sensitive fluids | Adding enzymes, vitamins, flavorings, and additives for fermentation | |
Aseptically transferring proteins and cells | Adding micro-organisms to fermentations, transferring blood or blood components, transferring products in filling processes | |
Adding additives | Additives, toxic chemicals | |
Injecting fluids for extrusion or spraying mechanisms | Producing active ingredients and tablets, adding stabilizers | |
Microfiltration and ultrafiltration, dialysis systems | Filtering process solutions, carefully concentrating intermediate products (biopharmaceuticals), concentrating and purifying protein solutions, separating cells and particles | |
High-pressure and supercritical applications | Dispersing 2 phases, supercritical processes with CO2, generating nanoparticles |
Solutions for the Pharmaceutical, Life Sciences, and Biotech Industries
The biopharmaceutical, fine chemical, veterinary medicine, and special food supplement industries all require systems that are easy to clean and drain, and that are manufactured and documented according to the applicable guidelines. LEWA has the expertise to design and construct customer-specific systems for these industries.
Our scope of supply for these sectors ranges from simple metering systems for metering additives, dosing modules in process chromatography units and buffer dilution systems, right through to complex systems for the proportional mixing or conveyance of various media.
Process-Integrated Pump Systems for Filtration and Other Processes
We also use the LEWA intellidrive technology to solve difficult metering and conveying tasks:
- Applications that allow a minimum of pulsation such as sensitive chromatography media or fluids during filtration processes
- Highly viscous fluids such as syrup or gel
- Highly precise metering during filling jobs
- Hermetically sealed for hygienic and sterile processes
- Mixing of two fluids in one pump head such as gradient formulation in chromatography processes
- At varying flow rates and at inhomogeneous qualities, changing pressures, or temperatures
Metering Pumps in Hygienic Design
LEWA hygienic metering pumps (LEWA ecodos and LEWA ecoflow) are hermetically sealed, leak-free, and have no connection, such as a shaft, to the product space. This ensures contamination-free metering and conveying over a long process time frame.
Hygienic pumps can also be used as multiplex pumps (e.g., for metering formulas). This means that several pump drive units can be assembled on one drive shaft. The individual pumps then convey varying quantities into the process. To increase the safety of your aseptic and sterile production processes, LEWA hygienic pumps are tested for their cleanability according to recognized, internationally valid guidelines (EHEDG cleanability test and QHD test system).
Advantages at a Glance
High end pumps, equipment and systems
We deliver high-end pumps integrated into complete systems and units for your specific applications. In doing so, we of course rely on the tried-and-tested LEWA quality.
Economic solutions
We always deliver economic pumps, systems and units with minimized energy consumption, high efficiency, low maintenance and a long lifetime.
Tried and tested modular system
We design our systems and units in modular design with numerous engine and pump head combinations for different applications.
Special materials
On request, we can build systems with special materials such as Hastelloy, titanium, duplex stainless steel or further materials. If you are interested, please contact our product manager.
Patented sandwich diaphragm
Our patented diaphragm metering pumps use metal or PTFE sandwich diaphragms with Diaphragm Protection System (DPS) for maximum operational safety.
Sanitary & hygienic design
Highly polished surfaces and a minimal dead space construction are the basis for a system design that meets all the industry's hygienic standards.
Easy to clean
An especially important advantage for pharmaceutical and food industry is that our systems can be quickly and easily cleaned with cleaning chemicals or hot steam.
International standards
LEWA pumps, systems and units are compliant with major international standards such as DVGW G280, WHG, PED, ISO 9001, ASME, ATEX and TA-Luft. Of course, you can also define your own standards.
Maintenance and service
No matter if maintenance, spare parts or repair - our service technicians are well trained and available worldwide. Thus, we guarantee fast response and smooth operations.
Applications
Downstream processing
LEWA systems and gradient mixers are used in downstream processing of chemicals and biotechnology. We look forward to receiving your inquiry!
More DetailsCaustic soda production
At LEWA, find out about custom plants for producing and diluting different bases like caustic soda. Ask our experts for more information.
More DetailsWet oxidation of waste water
For wet oxidation and other processes, we recommend our tried-and-tested LEWA diaphragm pumps. Ask our experts for more information!
More DetailsExtraction with supercritical fluids
Processes with supercritical fluids in pharmaceutical, food and beverage industries. Ask our experts for more information!
More DetailsPharmaceuticals production
Metering pumps and metering systems must meet the following demands of pharmaceutical production.
More DetailsChemical metering in high-pressure cleaning systems
LEWA metering and process diaphragm pumps meet the specific demands for the production of melamine (trimerization of urea). Consult us!
More DetailsPharmaceutical spray drying
LEWA provides accurate and efficient diaphragm metering pumps for pharmaceutical spray drying. Consult us!
More DetailsProduction of gelatine
In the production of gelatin and in the fabrication of gelatin products, LEWA pumps and systems are used. We would be happy to give you more information!
More DetailsHigh purity systems
Pumps and high purity systems from LEWA are a tried-and-tested solution in the pharmaceutical & biotechnology industry. We are happy to assist with your individual high purity system.
More DetailsProduction of creams
With its metering systems and diaphragm pumps, LEWA offers the right solution for recipe-compliant production of creams.
More DetailsMetering pumps for sterile applications
LEWA manufactures special aseptic solutions, for the metering of sensitive fluids. Ask our pharma experts for more information!
More DetailsProducts
LEWA ecoflow®: The Leading Diaphragm Metering Pump for Precision Fluid Management
LEWA ecoflow: The Innovative Universal Metering Pump with DPS Diaphragm Protection. Trusted across all industries, this modular system pump excels in a wide range of applications. Experience unparalleled versatility and reliability with our ecoflow, the ultimate choice in metering pump technology.
More DetailsLEWA ecoflow®: Advanced Hygienic Diaphragm Metering Pumps for Sanitary Applications
Discover the LEWA ecoflow® in its hygienic version, designed for sanitary applications. This versatile metering pump maintains its renowned all-around performance while meeting the stringent hygienic standards required in pharmaceutical and food production industries.
More DetailsLEWA ecosmart®: Precision-Engineered Diaphragm Metering Pumps for Efficient Fluid Control
Experience the innovative LEWA ecosmart, a compact diaphragm metering pump offering multiplex capabilities at a competitive price. We assure the renowned LEWA quality, backed by our 70 years of market expertise. Choose LEWA ecosmart for smart metering pump solutions without compromising on quality or performance.
More DetailsLEWA ecodos®: Robust Mechanical Diaphragm Metering Pumps for Precision Dosing
The LEWA ecodos metering pump delivers absolute reliability, cost-efficiency, and adaptability for applications preferring non-diaphragm actuation. Trust in our proven modular system to design the optimal metering pump tailored to your specific needs.
More DetailsLEWA ecodos®: Advanced Sanitary/Hygienic Diaphragm Metering Pumps for Precise Fluid Control
The LEWA ecodos is also offered in a sanitary/hygienic version, expertly meeting all operational standards for pharmaceutical and food production metering pumps.
More DetailsLEWA intellidrive®: Cutting-Edge Diaphragm Metering Pump Technology for Precision Fluid Management
Customize both suction and discharge strokes to fit your precise specifications with the LEWA intellidrive® diaphragm metering pump. This technology allows you to individually shape pumping characteristics, ensuring optimal metering for your applications.
More DetailsLEWA FC: High-Precision Laboratory Metering Pumps for Advanced Research Applications
Explore our precision metering pumps designed for micro-flow rates. The FC series, capable of handling pressures up to 400 bar, is tailor-made for laboratory and test center applications, offering unparalleled accuracy for small-scale fluid management.
More DetailsLEWA ecoflow®: The Leading Process Pumps for High-Pressure Applications
The innovative ecoflow diaphragm process pump excels in high-pressure applications across industries including oil and gas, refinery, petrochemicals, pharmaceuticals, biotechnology, and food and beverage production.
More DetailsLEWA triplex®: Compact Process Pumps for High-Pressure Applications
The LEWA triplex process diaphragm pump stands out as one of the world's most compact high-pressure pumps, ideal for installation in confined spaces. Renowned for its robustness, it has demonstrated exceptional performance across various high-pressure processes in multiple industries.
More DetailsPomac rotary lobe pump
The flexible and economical positive-displacement pump for hygienic standard applications all the way to complex sterile applications with low-viscosity, viscous and/or shear-sensitive media.
More DetailsPomac PDSP double screw pump
Pomac PDSP double-screw pumps are ideally suited for a variety of processes in the food, beverages, cosmetics and pharmaceutical industries. They are extremely economical because they are suitable for conveying and for sterilizing/cleaning (2 in 1).
More DetailsPomac centrifugal pump
The stainless-steel Pomac centrifugal pumps for low-viscosity media feature optimum hydraulic data, a unique modular design and numerous options available in the area of shaft seals. It is available in various versions.
More DetailsLEWA Bellows Pulsators
The perfect solution for generating oscillating fluid flows in vertical vessels for a quicker chemical reaction.
More DetailsCustomer-Specific Metering, Mixing or Filling Systems from LEWA
Customer-specific batch/continuous systems for your production process. Metering, mixing, filling, separating, controlling temperature: We work with you to develop the ideal process-related sequence and produce the system that fits your production process – right up to the end product.
More DetailsCustomer-Specific Metering Systems from LEWA
Turnkey metering system in closed loop control with monitoring and plausibility testing equipment. Your individually configured metering system with an optimally designed pump for fluid metering in automated processes.
More DetailsLEWA triplex®: High-Pressure Homogenizing Process Pumps
The LEWA triplex homogenizing pump utilizes hermetic diaphragm technology, making it ideal for sensitive applications such as ready-to-drink products, infant food, nutraceuticals, and enteral nutrition. Designed to handle demanding fluids, it finds optimal use in the food, beverage, and pharmaceutical industries.
More DetailsHNPM - Micro annular gear pump series HL
Micro annular gear pumps accomplish conventional micro fluidic tasks effectively and efficiently and open up new technological fields.
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